Tisch
DO IT FOR HER
Chandler's father was transgender but played by a cisgender woman (who has since said she regrets taking on the role).Despite liking it, some of the transphobia is shocking. Anything involving Chandler's mother (who I believe was supposed to be transgender but was always referred to as his father) is horrible and I probably would skip those episodes now
They also (of course) mixed up references to him being gay / a cross dresser / a drag queen / a transsexual throughout the show (not to mention it being the butt of the joke whenever the character was mentioned).
As for the country, in terms of social media/news coverage, reruns, merchandise, and general pop culture impact I'd say it's pretty much up there with Friends
Another one that fits in that category but isn't even a comedy to begin with, would be Grey's Anatomy.
Their representation of homosexuality was quite wonderful (mostly).